It was not immediately clear what provoked the standoff at the Ar-Rihiya Mosque south of Hebron, where two Palestinians were detained.
Local residents told Ma'an that Israeli forces ordered elderly residents to evacuate the facility, but they refused. Soldiers used several Palestinians as human shields while surrounding the mosque, onlookers said, during confrontations between local youth and soldiers who opened fire with tear-gas canisters, rubber-coated bullets, and live ammunition.
An Israeli military spokeswoman did not immediately return a call seeking comment.